This is something like " 500 Internal server error " or " Page not found" like that ? There are very basic and common situations like
1) Bandwidth or disc space or CPU/Ram/Inode usage reached its limit
2) htaccess isn't read/write able, permission issue or corrupted
3) incompatibility in plugin, theme or your server side core ( Eg: Php version, Apache missing necessary libraries,etc)
4) DNS records mismatch, memory usage , permalink, mod_rewrite bottleneck problems
5) Server hop latency, low performance hardware, security addons ( eg: CSF,symlinks,etc) may cause issues
However, it's all depends on what type of error that you are getting! always use updraft or backupbuddy to maintain incremental backup where you can restore or revert the changes from your end.
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